Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4CD25Foxp3regulatory T cells Running head: Protection of chronic GVHD by regulatory DCs
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چکیده
Chronic graft-versus-host disease (cGVHD) is a common cause of morbidity and mortality in allogeneic bone marrow transplantation (alloBMT). However, effective strategies for the treatment of cGVHD have not been established. In this study, we examined the therapeutic utility of modified dendritic cells (DCs) with a greater capacity to regulate immune responses than previously known tolerogenic DCs, regulatory DCs (DC reg), in the major histocompatibility complex (MHC)-compatible and multiple minor histocompatibility antigen (miHAg)-incompatible model of cGVHD in alloBMT. Treatment of the recipient mice following alloBMT with the recipient-type DC reg lead to greater suppression of the incidence and severity of cutaneous cGVHD than rapamycin (RAPA), whereas treatment with the recipient-type mature DCs (mDCs) promoted the pathogenesis. Analysis of the recipient mice suggested that the protective effect of the recipient-type DC reg involved the peripheral generation of alloreactive CD4
منابع مشابه
Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+ regulatory T cells.
Chronic graft-versus-host disease (cGVHD) is a common cause of morbidity and mortality in allogeneic bone marrow transplantation (alloBMT). However, effective strategies for the treatment of cGVHD have not been established. In this study, we examined the therapeutic utility of modified dendritic cells (DCs) with a greater capacity to regulate immune responses than previously known tolerogenic D...
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